Since milk thistle may mimic the effects of estrogen, some women should avoid this herb. For example, other antioxidants, such as vitamin C, are only able to accomplish this “cycling” process about four times. Silibinin also inhibited CD-44, a cell surface adhesion receptor that is highly expressed in many cancers, regulates metastasis and is also a bio-marker for cancer stem cells. He has a Professional Certificate in Food, Nutrition & Research from Wageningen University. Ramasamy K, Agarwal R. Multitargeted therapy of cancer by silymarin. The aromatase inhibitors work via inhibition of conversion of hormones like testosterone to estrogens and have no effect on exogenous (administered substance – not produced in the body) estrogenic substances like those found in Milk Thistle! Copyright © 2020 Dr. Michael Murray     | Website by Gill Brooks | Privacy Policy | Terms and Conditions, Face, Twitter!/DrMichaelMurray, Reducing after-meal elevations in blood glucose levels, Improving insulin function and sensitivity, Preventing nutritional and oxidative stress. PQQ has been found in all plant foods analyzed to date. What Are the Side Effects of Using Breast Enlargement Pills? 6) A J Notini, R A Davey, J F McManus, K L Bate and J D Zajac. There is a big hype regarding the soy being the biggest estrogenic evil and many people avoid soy even in trace amounts which is silly in my opinion. If you want to compare the dosage of 300 grams (0.3 kg) of Milk Thistle seeds to capsules of Milk Thistle extract you may buy as supplement it is like seventy 150 mg capsules of 80% silymarin extract (containing 120 mg of silymarin per capsule). • Inhibition of breast cancer cell growth and the inhibition of key pathways that cancer cells use to grow. ” Vet. This herbal medicine possesses antioxidant and anti-inflammatory properties and has several health benefits. Individuals using milk thistle have reported abdominal problems, allergic reactions, and interactions with estrogen and certain types of medications. “There was no evidence of carcinogenic activity.”. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). 2011 May;(565):1-177. Milk thistle supplements are commonly sold as in capsule form but are also available as tablets, tea bags, and oral tinctures. Also the weight of cows is about 1400 lbs on average (635 kg). So, consult a doctor to understand about its long term usage. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. The therapeutic effect of milk thistle extracts in these disorders has been confirmed by biopsy as well as by clinical and laboratory data. As usual, annoyance and irritation prods me to write an article in order to set the matter straight. Some studies have linked milk thistle compounds called silymarins with antioxidant and anti-inflammatory effects on the liver and other organs. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Interactions Milk thistle may interfere with the effects of estrogen replacement therapy and oral contraceptives due to its possible estrogenic effects. This site uses Akismet to reduce spam. Compliance and tolerability were also very good. The cows of test groups were given for a fortnight feed rations containing a meal of milk thistle (Silybum marianum, L., Gaert.) Phytosomes are a combination of silymarin with phosphatidylcholine molecules to aid their absorption. It is up to you to decide, the science and anecdotal experiences speak for themselves. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). You still think that Silymarin (Milk thistle extract) is the best option for your liver? He considers himself a sculptor born to chip away at content and reveal its dormant splendor. Updated June 12, 2019. Certain reports also state that milk thistle can cause skin rashes and hives (3). Phytoestrogens – Harmful or Beneficial for Hormone Driven Breast Cancer? Bosch-Barrera J, Menendez JA. Natl Toxicol Program Tech Rep Ser. Silymarin administration significantly affected the levels of Thyroid hormones in rats after 30 days of treatment.To compare the silymarin effects to estradiol the researchers administered the other group of rats 5 mcg of estradiol daily for the last 3 days. 2008;269: 352-362. Silibinin was once thought to be a single compound but is now recognized as a 1:1 mixture of 2 diastereoisomers, silybin A and silybin B. kiwiPQQ (short for pyrroloquinoline quinone) is a vitamin-like compound found in plant foods that shows a wide range of benefits for brain function and energy production. While it could also cause drug interactions, research is mixed. You can read more about the Ursodeoxycholic acid in my previous post “Bile acids toxicity, endotoxins and leaky gut”.

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